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Engagement of CD153 (CD30 Ligand) by CD30(+) T Cells Inhibits Class Switch DNA Recombination and Antibody Production in Human IgD(+) IgM(+) B Cells()

CD153 (CD30 ligand) is a member of the TNF ligand/cytokine family expressed on the surface of human B cells. Upon exposure to IL-4, a critical Ig class switch-inducing cytokine, Ag-activated T cells express CD30, the CD153 receptor. The observation that dysregulated IgG, IgA, and/or IgE production i...

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Publicat a:J Immunol
Autors principals: Cerutti, Andrea, Schaffer, Andràs, Goodwin, Raymond G., Shah, Shefali, Zan, Hong, Ely, Scott, Casali, Paolo
Format: Artigo
Idioma:Inglês
Publicat: 2000
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621014/
https://ncbi.nlm.nih.gov/pubmed/10878352
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