Dysregulation of CD30(+) T cells by leukemia impairs isotype switching in normal B cells

Chronic lymphocytic leukemia (CLL) is associated with impaired immunoglobulin (Ig) class-switching from IgM to IgG and IgA, a defect that leads to recurrent infections. When activated in the presence of leukemic CLL B cells, T cells rapidly up-regulate CD30 through an OX40 ligand and interleukin 4 (...

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Bibliografske podrobnosti
izdano v:Nat Immunol
Main Authors: Cerutti, Andrea, Kim, Edmund C., Shah, Shefali, Schattner, Elaine J., Zan, Hong, Schaffer, András, Casali, Paolo
Format: Artigo
Jezik:Inglês
Izdano: 2001
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621971/
https://ncbi.nlm.nih.gov/pubmed/11175813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/84254
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