CD30 Is a CD40-Inducible Molecule that Negatively Regulates CD40-Mediated Immunoglobulin Class Switching in Non-Antigen-Selected Human B Cells

We used our monoclonal model of germinal center maturation, CL-01 B cells, to investigate the role of CD30 in human B cell differentiation. CL-01 cells are IgM(+)IgD(+)CD30(+) and switch to IgG, IgA, and IgE when exposed to CD40L and IL-4. Switching is hampered by CD30 coengagement, possibly through...

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Bibliografske podrobnosti
izdano v:Immunity
Main Authors: Cerutti, Andrea, Schaffer, András, Shah, Shefali, Zan, Hong, Liou, Hsiou-Chi, Goodwin, Raymond G., Casali, Paolo
Format: Artigo
Jezik:Inglês
Izdano: 1998
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4621001/
https://ncbi.nlm.nih.gov/pubmed/9729045
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