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Dysregulation of CD30(+) T cells by leukemia impairs isotype switching in normal B cells
Chronic lymphocytic leukemia (CLL) is associated with impaired immunoglobulin (Ig) class-switching from IgM to IgG and IgA, a defect that leads to recurrent infections. When activated in the presence of leukemic CLL B cells, T cells rapidly up-regulate CD30 through an OX40 ligand and interleukin 4 (...
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| Pubblicato in: | Nat Immunol |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2001
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4621971/ https://ncbi.nlm.nih.gov/pubmed/11175813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/84254 |
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