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Controlling somatic hypermutation in immunoglobulin variable and switch regions
Activation-induced deaminase (AID) is a B-cell specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in th...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952935/ https://ncbi.nlm.nih.gov/pubmed/20082153 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12026-009-8142-5 |
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