Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions

Activation-induced deaminase (AID) initiates diversity of immunoglobulin genes through deamination of cytosine to uracil. Two opposing models have been proposed for the deamination of DNA or RNA by AID. Although most data support DNA deamination, there is no physical evidence of uracil residues in i...

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Bibliografiska uppgifter
Huvudupphovsmän: Maul, Robert W, Saribasak, Huseyin, Martomo, Stella A, McClure, Rhonda L, Yang, William, Vaisman, Alexandra, Gramlich, Hillary S, Schatz, David G, Woodgate, Roger, Wilson, David M, Gearhart, Patricia J
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2010
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653439/
https://ncbi.nlm.nih.gov/pubmed/21151102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.1970
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