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In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.
Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class-switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, the...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2001
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1087687/ https://ncbi.nlm.nih.gov/pubmed/11205326 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2000.0744 |
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