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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID
High-affinity antibodies are generated by somatic hypermutation with nucleotide substitutions introduced into the IgV in a semirandom fashion, but with intrinsic mutational hotspots strategically located to optimize antibody affinity maturation. The process is dependent on activation-induced deamina...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
The Rockefeller University Press
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2812546/ https://ncbi.nlm.nih.gov/pubmed/20048284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092238 |
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