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Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID

High-affinity antibodies are generated by somatic hypermutation with nucleotide substitutions introduced into the IgV in a semirandom fashion, but with intrinsic mutational hotspots strategically located to optimize antibody affinity maturation. The process is dependent on activation-induced deamina...

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Autori principali: Wang, Meng, Rada, Cristina, Neuberger, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2812546/
https://ncbi.nlm.nih.gov/pubmed/20048284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20092238
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