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Immunoglobulin somatic hypermutation by APOBEC3/Rfv3 during retroviral infection
Somatic hypermutation (SHM) is an integral process in the development of high-affinity antibodies that are important for recovery from viral infections and vaccine-induced protection. Ig SHM occurs predominantly in germinal centers (GC) via the enzymatic activity of activation-induced deaminase (AID...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4040588/ https://ncbi.nlm.nih.gov/pubmed/24821801 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403361111 |
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