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Computational design of antibody affinity improvement beyond in vivo maturation

Antibodies are used extensively in diagnostics and as therapeutic agents. Achieving high-affinity binding is important for expanding detection limits, extending dissociation half-times, decreasing drug dosages, and increasing drug efficacy. However, antibody affinity maturation in vivo often fails t...

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Detalhes bibliográficos
Main Authors: Lippow, Shaun M., Wittrup, K. Dane, Tidor, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803018/
https://ncbi.nlm.nih.gov/pubmed/17891135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1336
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