Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design

Antibodies are an important class of therapeutics that have significant clinical impact for the treatment of severe diseases. Computational tools to support antibody drug discovery have been developing at an increasing rate over the last decade and typically rely upon a predetermined co-crystal stru...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Cannon, Daniel A., Shan, Lu, Du, Qun, Shirinian, Lena, Rickert, Keith W., Rosenthal, Kim L., Korade, Martin, van Vlerken-Ysla, Lilian E., Buchanan, Andrew, Vaughan, Tristan J., Damschroder, Melissa M., Popovic, Bojana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6513101/
https://ncbi.nlm.nih.gov/pubmed/31042706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006980
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