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Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity
The aggregation of amyloidogenic polypeptides is strongly linked to several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Conformational antibodies that selectively recognize protein aggregates are leading therapeutic agents for selectively neutralizing toxic aggregate...
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8081927/ https://ncbi.nlm.nih.gov/pubmed/33675750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100508 |
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