Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

The aggregation of amyloidogenic polypeptides is strongly linked to several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Conformational antibodies that selectively recognize protein aggregates are leading therapeutic agents for selectively neutralizing toxic aggregate...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081927/
https://ncbi.nlm.nih.gov/pubmed/33675750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100508
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados