Rational affinity maturation of anti-amyloid antibodies with high conformational and sequence specificity

The aggregation of amyloidogenic polypeptides is strongly linked to several neurodegenerative disorders, including Alzheimer’s and Parkinson’s diseases. Conformational antibodies that selectively recognize protein aggregates are leading therapeutic agents for selectively neutralizing toxic aggregate...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Desai, Alec A., Smith, Matthew D., Zhang, Yulei, Makowski, Emily K., Gerson, Julia E., Ionescu, Edward, Starr, Charles G., Zupancic, Jennifer M., Moore, Shannon J., Sutter, Alexandra B., Ivanova, Magdalena I., Murphy, Geoffrey G., Paulson, Henry L., Tessier, Peter M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2021
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC8081927/
https://ncbi.nlm.nih.gov/pubmed/33675750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbc.2021.100508
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