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Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation

Integrins are important cell surface receptors that transmit bidirectional signals across the membrane. It has been shown that a conformational change of the integrin β-subunit headpiece (i.e. the β I domain and the hybrid domain) plays a critical role in regulating integrin ligand binding affinity...

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Bibliografiske detaljer
Main Authors: Luo, Bing-Hao, Karanicolas, John, Harmacek, Laura D., Baker, David, Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635054/
https://ncbi.nlm.nih.gov/pubmed/19019827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806312200
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