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Rationally Designed Integrin β3 Mutants Stabilized in the High Affinity Conformation
Integrins are important cell surface receptors that transmit bidirectional signals across the membrane. It has been shown that a conformational change of the integrin β-subunit headpiece (i.e. the β I domain and the hybrid domain) plays a critical role in regulating integrin ligand binding affinity...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Biochemistry and Molecular Biology
2009
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635054/ https://ncbi.nlm.nih.gov/pubmed/19019827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806312200 |
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