Evolution of Biologics Screening Technologies

Por Cariuk, Peter, Gardener, Matthew J., Vaughan, Tristan J.
Publicado em 2013

Overcoming the Refractory Expression of Secreted Recombinant Proteins in Mammalian Cells through Modification of the Signal Peptide and Adjacent Amino Acids

Por Güler-Gane, Gülin, Kidd, Sara, Sridharan, Sudharsan, Vaughan, Tristan J., Wilkinson, Trevor C. I., Tigue, Natalie J.
Publicado no PLoS One (2016)

Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing i...

Por Groves, Maria AT, Amanuel, Lily, Campbell, Jamie I, Rees, D Gareth, Sridharan, Sudharsan, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Publicado em 2014

Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

Por Dobson, Claire L, Main, Sarah, Newton, Philip, Chodorge, Matthieu, Cadwallader, Karen, Humphreys, Robin, Albert, Vivian, Vaughan, Tristan J, Minter, Ralph R, Edwards, Bryan M
Publicado em 2009

Phage display and hybridoma generation of antibodies to human CXCR2 yields antibodies with distinct mechanisms and epitopes

Por Rossant, Christine J, Carroll, Danielle, Huang, Ling, Elvin, John, Neal, Frances, Walker, Edward, Benschop, Joris J, Kim, Eldar E, Barry, Simon T, Vaughan, Tristan J
Publicado no MAbs (2014)

Affinity maturation of a novel antagonistic human monoclonal antibody with a long V(H) CDR3 targeting the Class A GPCR formyl-peptide receptor 1

Por Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Publicado no MAbs (2014)

Generation of potent mouse monoclonal antibodies to self-proteins using T-cell epitope “tags”

Por Percival-Alwyn, Jennifer L, England, Elizabeth, Kemp, Benjamin, Rapley, Laura, Davis, Nicola HE, McCarthy, Grant R, Majithiya, Jayesh B, Corkill, Dominic J, Welsted, Sarah, Minton, Kevin, Cohen, E Suzanne, Robinson, Matthew J, Dobson, Claire, Wilkinson, Trevor CI, Vaughan, Tristan J, Groves, Maria AT, Tigue, Natalie J
Publicado no MAbs (2014)

Structure and characterization of a high affinity C5a monoclonal antibody that blocks binding to C5aR1 and C5aR2 receptors

Por Colley, Caroline S., Popovic, Bojana, Sridharan, Sudharsan, Debreczeni, Judit E., Hargeaves, David, Fung, Michael, An, Ling–Ling, Edwards, Bryan, Arnold, Joanne, England, Elizabeth, Eghobamien, Laura, Sivars, Ulf, Flavell, Liz, Renshaw, Jonathan, Wickson, Kate, Warrener, Paul, Zha, Jingying, Bonnell, Jessica, Woods, Rob, Wilkinson, Trevor, Dobson, Claire, Vaughan, Tristan J.
Publicado no MAbs (2017)

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

Por Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.
Publicado no Sci Rep (2016)

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

Por Cohen, E. Suzanne, Scott, Ian C., Majithiya, Jayesh B., Rapley, Laura, Kemp, Benjamin P., England, Elizabeth, Rees, D. Gareth, Overed-Sayer, Catherine L., Woods, Joanne, Bond, Nicholas J., Veyssier, Christel Séguy, Embrey, Kevin J., Sims, Dorothy A., Snaith, Michael R., Vousden, Katherine A., Strain, Martin D., Chan, Denice T. Y., Carmen, Sara, Huntington, Catherine E., Flavell, Liz, Xu, Jianqing, Popovic, Bojana, Brightling, Christopher E., Vaughan, Tristan J., Butler, Robin, Lowe, David C., Higazi, Daniel R., Corkill, Dominic J., May, Richard D., Sleeman, Matthew A., Mustelin, Tomas
Publicado no Nat Commun (2015)