Affinity maturation of a novel antagonistic human monoclonal antibody with a long V(H) CDR3 targeting the Class A GPCR formyl-peptide receptor 1

Therapeutic monoclonal antibodies targeting G-protein-coupled receptors (GPCRs) are desirable for intervention in a wide range of disease processes. The discovery of such antibodies is challenging due to a lack of stability of many GPCRs as purified proteins. We describe here the generation of Fpro0...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:MAbs
Main Authors: Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2014
Fag:
Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622665/
https://ncbi.nlm.nih.gov/pubmed/25484051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985158
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker