Affinity maturation of a novel antagonistic human monoclonal antibody with a long V(H) CDR3 targeting the Class A GPCR formyl-peptide receptor 1

Therapeutic monoclonal antibodies targeting G-protein-coupled receptors (GPCRs) are desirable for intervention in a wide range of disease processes. The discovery of such antibodies is challenging due to a lack of stability of many GPCRs as purified proteins. We describe here the generation of Fpro0...

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Bibliografische gegevens
Gepubliceerd in:MAbs
Hoofdauteurs: Douthwaite, Julie A, Sridharan, Sudharsan, Huntington, Catherine, Hammersley, Jayne, Marwood, Rose, Hakulinen, Jonna K, Ek, Margareta, Sjögren, Tove, Rider, David, Privezentzev, Cyril, Seaman, Jonathan C, Cariuk, Peter, Knights, Vikki, Young, Joyce, Wilkinson, Trevor, Sleeman, Matthew, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Taylor & Francis 2014
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Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622665/
https://ncbi.nlm.nih.gov/pubmed/25484051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/19420862.2014.985158
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