Length-independent structural similarities enrich the antibody CDR canonical class model

Complementarity-determining regions (CDRs) are antibody loops that make up the antigen binding site. Here, we show that all CDR types have structurally similar loops of different lengths. Based on these findings, we created length-independent canonical classes for the non-H3 CDRs. Our length variabl...

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Detalhes bibliográficos
Publicado no:MAbs
Main Authors: Nowak, Jaroslaw, Baker, Terry, Georges, Guy, Kelm, Sebastian, Klostermann, Stefan, Shi, Jiye, Sridharan, Sudharsan, Deane, Charlotte M.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4966832/
https://ncbi.nlm.nih.gov/pubmed/26963563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2016.1158370
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