Antibody VH and VL recombination using phage and ribosome display technologies reveals distinct structural routes to affinity improvements with VH-VL interface residues providing important structural diversity

In vitro selection technologies are an important means of affinity maturing antibodies to generate the optimal therapeutic profile for a particular disease target. Here, we describe the isolation of a parent antibody, KENB061 using phage display and solution phase selections with soluble biotinylate...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Groves, Maria AT, Amanuel, Lily, Campbell, Jamie I, Rees, D Gareth, Sridharan, Sudharsan, Finch, Donna K, Lowe, David C, Vaughan, Tristan J
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3929446/
https://ncbi.nlm.nih.gov/pubmed/24256948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27261
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados