Human monomeric antibody fragments to TRAIL-R1 and TRAIL-R2 that display potent in vitro agonism

Apoptosis through the TRAIL receptor pathway can be induced via agonistic IgG to either TRAIL-R1 or TRAIL-R2. Here we describe the use of phage display to isolate a substantive panel of fully human anti-TRAIL receptor single chain Fv fragments (scFvs); 234 and 269 different scFvs specific for TRAIL-...

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Bibliografiske detaljer
Main Authors: Dobson, Claire L, Main, Sarah, Newton, Philip, Chodorge, Matthieu, Cadwallader, Karen, Humphreys, Robin, Albert, Vivian, Vaughan, Tristan J, Minter, Ralph R, Edwards, Bryan M
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2009
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Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791312/
https://ncbi.nlm.nih.gov/pubmed/20068388
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