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Computational design of antibody affinity improvement beyond in vivo maturation
Antibodies are used extensively in diagnostics and as therapeutic agents. Achieving high-affinity binding is important for expanding detection limits, extending dissociation half-times, decreasing drug dosages, and increasing drug efficacy. However, antibody affinity maturation in vivo often fails t...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2803018/ https://ncbi.nlm.nih.gov/pubmed/17891135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt1336 |
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