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Context-dependent mutations predominate in an engineered high-affinity single chain antibody fragment
A mutational analysis of the femtomolar-affinity anti-fluorescein antibody 4M5.3, compared to its wild-type progenitor, 4-4-20, indicates both context-dependent and -independent mutations are responsible for the 1800-fold affinity improvement. 4M5.3 was engineered from 4-4-20 by directed evolution a...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2242459/ https://ncbi.nlm.nih.gov/pubmed/16434745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.051842406 |
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