Molecular Engineering of High Affinity Single-chain Antibody Fragment for Endothelial Targeting of Proteins and Nanocarriers in Rodents and Humans

Endothelial cells (EC) represent an important target for pharmacologic intervention, given their central role in a wide variety of human pathophysiologic processes. Studies in lab animal species have established that conjugation of drugs and carriers with antibodies directed to surface targets like...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Greineder, Colin F., Hood, Elizabeth D., Yao, Anning, Khoshnejad, Makan, Brenner, Jake S., Johnston, Ian H, Poncz, Mortimer, Gottstein, Claudia, Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4964279/
https://ncbi.nlm.nih.gov/pubmed/26855052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2016.02.006
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