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Inhibiting Alternative Pathway Complement Activation by Targeting the Factor D Exosite
By virtue of its amplifying property, the alternative complement pathway has been implicated in a number of inflammatory diseases and constitutes an attractive therapeutic target. An anti-factor D Fab fragment (AFD) was generated to inhibit the alternative complement pathway in advanced dry age-rela...
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| Autors principals: | , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3339934/ https://ncbi.nlm.nih.gov/pubmed/22362762 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.345082 |
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