Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predis...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943270/
https://ncbi.nlm.nih.gov/pubmed/29743491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25557-8
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