Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predis...

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Pubblicato in:Sci Rep
Autori principali: Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5943270/
https://ncbi.nlm.nih.gov/pubmed/29743491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25557-8
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