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Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation
CRIg is a recently discovered complement C3 receptor expressed on a subpopulation of tissue-resident macrophages. The extracellular IgV domain of CRIg (CRIg-ECD) holds considerable promise as a potential therapeutic because it selectively inhibits the alternative pathway of complement by binding to...
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| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790991/ https://ncbi.nlm.nih.gov/pubmed/19833734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035170 |
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