Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation

CRIg is a recently discovered complement C3 receptor expressed on a subpopulation of tissue-resident macrophages. The extracellular IgV domain of CRIg (CRIg-ECD) holds considerable promise as a potential therapeutic because it selectively inhibits the alternative pathway of complement by binding to...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Li, Bing, Xi, Hongkang, Diehl, Lauri, Lee, Wyne P., Sturgeon, Lizette, Chinn, Jason, DeForge, Laura, Kelley, Robert F., Wiesmann, Christian, van Lookeren Campagne, Menno, Sidhu, Sachdev S.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2009
Sujets:
Protein Structure and Folding
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790991/
https://ncbi.nlm.nih.gov/pubmed/19833734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.035170
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