Preclinical pharmacokinetics, pharmacodynamics, and activity of a humanized anti-CD40 antibody (SGN-40) in rodents and non-human primates

Por Kelley, Sean K, Gelzleichter, Thomas, Xie, Dong, Lee, Wyne P, Darbonne, Walter C, Qureshi, Ferhan, Kissler, Kim, Oflazoglu, Ezogelin, Grewal, Iqbal S
Publicado em 2006

Autoimmunity-associated protein tyrosine phosphatase PEP negatively regulates IFN-α receptor signaling

Por Holmes, Derek A., Suto, Eric, Lee, Wyne P., Ou, Qinglin, Gong, Qian, Smith, Hamish R.C., Caplazi, Patrick, Chan, Andrew C.
Publicado no J Exp Med (2015)

The Ox40/Ox40 Ligand Pathway Promotes Pathogenic Th Cell Responses, Plasmablast Accumulation, and Lupus Nephritis in NZB/W F1 Mice

Por Sitrin, Jonathan, Suto, Eric, Wuster, Arthur, Eastham-Anderson, Jeffrey, Kim, Jeong M., Austin, Cary D., Lee, Wyne P., Behrens, Timothy W.
Publicado no J Immunol (2017)

Genetic deletion of JAM-C reveals a role in myeloid progenitor generation

Por Praetor, Asja, McBride, Jacqueline M., Chiu, Henry, Rangell, Linda, Cabote, Lorena, Lee, Wyne P., Cupp, James, Danilenko, Dimitry M., Fong, Sherman
Publicado em 2009

Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation

Por Chang, Michael C., Srinivasan, Karpagam, Friedman, Brad A., Suto, Eric, Modrusan, Zora, Lee, Wyne P., Kaminker, Joshua S., Hansen, David V., Sheng, Morgan
Publicado no J Exp Med (2017)

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Por Lamkanfi, Mohamed, Mueller, James L., Vitari, Alberto C., Misaghi, Shahram, Fedorova, Anna, Deshayes, Kurt, Lee, Wyne P., Hoffman, Hal M., Dixit, Vishva M.
Publicado em 2009

IL-22R Ligands IL-20, IL-22, and IL-24 Promote Wound Healing in Diabetic db/db Mice

Por Kolumam, Ganesh, Wu, Xiumin, Lee, Wyne P., Hackney, Jason A., Zavala-Solorio, Jose, Gandham, Vineela, Danilenko, Dimitry M., Arora, Puneet, Wang, Xiaoting, Ouyang, Wenjun
Publicado no PLoS One (2017)

Caspase-11 auto-proteolysis is crucial for noncanonical inflammasome activation

Por Lee, Bettina L., Stowe, Irma B., Gupta, Aaron, Kornfeld, Opher S., Roose-Girma, Merone, Anderson, Keith, Warming, Søren, Zhang, Juan, Lee, Wyne P., Kayagaki, Nobuhiko
Publicado no J Exp Med (2018)

VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain

Por van Bruggen, Nicholas, Thibodeaux, Harold, Palmer, James T., Lee, Wyne P., Fu, Ling, Cairns, Belinda, Tumas, Daniel, Gerlai, Robert, Williams, Simon-Peter, Campagne, Menno van Lookeren, Ferrara, Napoleone
Publicado em 1999

Improving Therapeutic Efficacy of a Complement Receptor by Structure-based Affinity Maturation

Por Li, Bing, Xi, Hongkang, Diehl, Lauri, Lee, Wyne P., Sturgeon, Lizette, Chinn, Jason, DeForge, Laura, Kelley, Robert F., Wiesmann, Christian, van Lookeren Campagne, Menno, Sidhu, Sachdev S.
Publicado em 2009

Actin-Bundling Protein L-Plastin Regulates T Cell Activation

Por Wang, Chen, Morley, Sharon Celeste, Donermeyer, David, Peng, Ivan, Lee, Wyne P., Devoss, Jason, Danilenko, Dimitry M., Lin, Zhonghua, Zhang, Juan, Zhou, Jie, Allen, Paul M., Brown, Eric J.
Publicado em 2010

LACC1 Regulates TNF and IL-17 in Mouse Models of Arthritis and Inflammation

Por Skon-Hegg, Cara, Zhang, Juan, Wu, Xiumin, Sagolla, Meredith, Ota, Naruhisa, Wuster, Arthur, Tom, Jennifer, Doran, Emma, Ramamoorthi, Nandhini, Caplazi, Patrick, Monroe, John, Lee, Wyne P., Behrens, Timothy W.
Publicado no J Immunol (2019)

Dual B Cell Immunotherapy Is Superior to Individual Anti-CD20 Depletion or BAFF Blockade in Murine Models of Spontaneous or Accelerated Lupus

Por Lin, WeiYu, Seshasayee, Dhaya, Lee, Wyne P, Caplazi, Patrick, McVay, Sami, Suto, Eric, Nguyen, Allen, Lin, Zhonghua, Sun, Yonglian, DeForge, Laura, Balazs, Mercedesz, Martin, Flavius, Zarrin, Ali A
Publicado no Arthritis Rheumatol (2015)

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

Por Zhang, Zhen, Newton, Kim, Kummerfeld, Sarah K., Webster, Joshua, Kirkpatrick, Donald S., Phu, Lilian, Eastham-Anderson, Jeffrey, Liu, Jinfeng, Lee, Wyne P., Wu, Jiansheng, Li, Hong, Junttila, Melissa R., Dixit, Vishva M.
Publicado no Proc Natl Acad Sci U S A (2017)

Coordinated ubiquitination and phosphorylation of RIP1 regulates necroptotic cell death

Por de Almagro, M Cristina, Goncharov, Tatiana, Izrael-Tomasevic, Anita, Duttler, Stefanie, Kist, Matthias, Varfolomeev, Eugene, Wu, Xiumin, Lee, Wyne P, Murray, Jeremy, Webster, Joshua D, Yu, Kebing, Kirkpatrick, Donald S, Newton, Kim, Vucic, Domagoj
Publicado no Cell Death Differ (2017)

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

Por Chiang, Eugene Y., Li, Tianbo, Jeet, Surinder, Peng, Ivan, Zhang, Juan, Lee, Wyne P., DeVoss, Jason, Caplazi, Patrick, Chen, Jun, Warming, Søren, Hackos, David H., Mukund, Susmith, Koth, Christopher M., Grogan, Jane L.
Publicado no Nat Commun (2017)

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

Por Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M, van Lookeren Campagne, Menno
Publicado no Sci Rep (2018)

Publisher Correction: Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

Por Katschke, Kenneth J., Xi, Hongkang, Cox, Christian, Truong, Tom, Malato, Yann, Lee, Wyne P., McKenzie, Brent, Arceo, Rommel, Tao, Jianhua, Rangell, Linda, Reichelt, Mike, Diehl, Lauri, Elstrott, Justin, Weimer, Robby M., van Lookeren Campagne, Menno
Publicado no Sci Rep (2018)

A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis

Por Katschke, Kenneth J., Helmy, Karim Y., Steffek, Micah, Xi, Hongkang, Yin, JianPing, Lee, Wyne P., Gribling, Peter, Barck, Kai H., Carano, Richard A.D., Taylor, Robin E., Rangell, Linda, Diehl, Lauri, Hass, Philip E., Wiesmann, Christian, van Lookeren Campagne, Menno
Publicado em 2007

IL-33 amplifies an innate immune response in the degenerating retina

Por Xi, Hongkang, Katschke, Kenneth J., Li, Yun, Truong, Tom, Lee, Wyne P., Diehl, Lauri, Rangell, Linda, Tao, Jianhua, Arceo, Rommel, Eastham-Anderson, Jeffrey, Hackney, Jason A., Iglesias, Antonio, Cote-Sierra, Javier, Elstrott, Justin, Weimer, Robby M., van Lookeren Campagne, Menno
Publicado no J Exp Med (2016)