A carregar...
Progranulin deficiency causes impairment of autophagy and TDP-43 accumulation
Loss-of-function mutations in GRN cause frontotemporal dementia (FTD) with transactive response DNA-binding protein of 43 kD (TDP-43)–positive inclusions and neuronal ceroid lipofuscinosis (NCL). There are no disease-modifying therapies for either FTD or NCL, in part because of a poor understanding...
Na minha lista:
| Publicado no: | J Exp Med |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5584112/ https://ncbi.nlm.nih.gov/pubmed/28778989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160999 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|