Učitavanje...
Progranulin and TDP-43: Mechanistic Links and Future Directions
Loss-of-function mutations in the multifunctional growth factor progranulin (GRN) cause frontotemporal lobar degeneration (FTLD) with TDP-43 protein accumulation. Nuclear TDP-43 protein with key roles in RNA metabolism is also aggregated in amyotrophic lateral sclerosis (ALS), suggesting that ALS an...
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| Glavni autor: | |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Humana Press Inc
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3207122/ https://ncbi.nlm.nih.gov/pubmed/21863317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12031-011-9625-0 |
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