The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels

Mutations in the human progranulin gene resulting in protein haploinsufficiency cause frontotemporal lobar degeneration with TDP-43 inclusions. Although progress has been made in understanding the normal functions of progranulin and TDP-43, the molecular interactions between these proteins remain un...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Neurosci
Prif Awduron: Salazar, Dominique A., Butler, Victoria J., Argouarch, Andrea R., Hsu, Tsung-Yuan, Mason, Amanda, Nakamura, Ayumi, McCurdy, Helen, Cox, David, Ng, Rachel, Pan, Gloria, Seeley, William W., Miller, Bruce L., Kao, Aimee W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Society for Neuroscience 2015
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4478251/
https://ncbi.nlm.nih.gov/pubmed/26109656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4808-14.2015
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg