Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Aberrant aggregation of RNA binding protein TDP-43 in neurons is a hallmark of frontotemporal lobar degeneration caused by progranulin haploinsufficiency(1,2). However, the mechanism leading to TDP-43 proteinopathy remains unclear. Here we use single-nucleus RNA-sequencing (snRNA-seq) to show that p...

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Publicado no:Nature
Main Authors: Zhang, Jiasheng, Velmeshev, Dmitry, Hashimoto, Kei, Huang, Yu-Hsin, Hofmann, Jeffrey W., Shi, Xiaoyu, Chen, Jiapei, Leidal, Andrew M., Dishart, Julian G., Cahill, Michelle K., Kelley, Kevin W., Liddelow, Shane A., Seeley, William W., Miller, Bruce L., Walther, Tobias C., Farese, Robert V., Taylor, J. Paul, Ullian, Erik M., Huang, Bo, Debnath, Jayanta, Wittmann, Torsten, Kriegstein, Arnold R., Huang, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7746606/
https://ncbi.nlm.nih.gov/pubmed/32866962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2709-7
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