Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene encoding progranulin (GRN), which lead to...

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Bibliografiska uppgifter
Huvudupphovsmän: Ward, Michael E., Taubes, Alice, Chen, Robert, Miller, Bruce L., Sephton, Chantelle F., Gelfand, Jeffrey M., Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W., Yu, Gang, Herz, Joachim, Filiano, Anthony J., Arrant, Andrew E., Roberson, Erik D., Kraft, Timothy W., Farese, Robert V., Green, Ari, Gan, Li
Materialtyp: Artigo
Språk:Inglês
Publicerad: The Rockefeller University Press 2014
Ämnen:
Brief Definitive Report
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172214/
https://ncbi.nlm.nih.gov/pubmed/25155018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140214
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