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Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene encoding progranulin (GRN), which lead to...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ward, Michael E., Taubes, Alice, Chen, Robert, Miller, Bruce L., Sephton, Chantelle F., Gelfand, Jeffrey M., Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W., Yu, Gang, Herz, Joachim, Filiano, Anthony J., Arrant, Andrew E., Roberson, Erik D., Kraft, Timothy W., Farese, Robert V., Green, Ari, Gan, Li
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Rockefeller University Press 2014
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172214/
https://ncbi.nlm.nih.gov/pubmed/25155018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140214
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