Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD

Frontotemporal dementia (FTD) is the most common cause of dementia in people under 60 yr of age and is pathologically associated with mislocalization of TAR DNA/RNA binding protein 43 (TDP-43) in approximately half of cases (FLTD-TDP). Mutations in the gene encoding progranulin (GRN), which lead to...

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Main Authors: Ward, Michael E., Taubes, Alice, Chen, Robert, Miller, Bruce L., Sephton, Chantelle F., Gelfand, Jeffrey M., Minami, Sakura, Boscardin, John, Martens, Lauren Herl, Seeley, William W., Yu, Gang, Herz, Joachim, Filiano, Anthony J., Arrant, Andrew E., Roberson, Erik D., Kraft, Timothy W., Farese, Robert V., Green, Ari, Gan, Li
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2014
主題:
Brief Definitive Report
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172214/
https://ncbi.nlm.nih.gov/pubmed/25155018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140214
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