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Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration

GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN mutations were detected in two patients with neuronal ceroid lipofuscinosis, a lysosomal storage disease. It is unknown whether the pat...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Cenik, Basar, Sephton, Chantelle F., Kutluk Cenik, Bercin, Herz, Joachim, Yu, Gang
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3463300/
https://ncbi.nlm.nih.gov/pubmed/22859297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R112.399170
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