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Progranulin: A Proteolytically Processed Protein at the Crossroads of Inflammation and Neurodegeneration
GRN mutations cause frontotemporal lobar degeneration with TDP-43-positive inclusions. The mechanism of pathogenesis is haploinsufficiency. Recently, homozygous GRN mutations were detected in two patients with neuronal ceroid lipofuscinosis, a lysosomal storage disease. It is unknown whether the pat...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3463300/ https://ncbi.nlm.nih.gov/pubmed/22859297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.R112.399170 |
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