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TDP-43 Aggregation In Neurodegeneration: Are Stress Granules The Key?

The RNA-binding protein TDP-43 is strongly linked to neurodegeneration. Not only are mutations in the gene encoding TDP-43 associated with ALS and FTLD, but this protein is also a major constituent of pathological intracellular inclusions in these diseases. Recent studies have significantly expanded...

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Detalles Bibliográficos
Main Authors: Dewey, Colleen M., Cenik, Basar, Sephton, Chantelle F., Johnson, Brett A., Herz, Joachim, Yu, Gang
Formato: Artigo
Idioma:Inglês
Publicado: 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372581/
https://ncbi.nlm.nih.gov/pubmed/22405725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2012.02.032
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