Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)

Progranulin is a secreted glycoprotein, and the GRN gene is mutated in some cases of frontotemporal dementia. Progranulin has also been implicated in cell growth, wound healing, inflammation, and cancer. We investigated the molecular nature of secreted progranulin and provide evidence that progranul...

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Bibliographic Details
Main Authors: Nguyen, Andrew D., Nguyen, Thi A., Cenik, Basar, Yu, Gang, Herz, Joachim, Walther, Tobias C., Davidson, W. Sean, Farese, Robert V.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Lipids
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605681/
https://ncbi.nlm.nih.gov/pubmed/23364791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441949
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