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Secreted Progranulin Is a Homodimer and Is Not a Component of High Density Lipoproteins (HDL)

Progranulin is a secreted glycoprotein, and the GRN gene is mutated in some cases of frontotemporal dementia. Progranulin has also been implicated in cell growth, wound healing, inflammation, and cancer. We investigated the molecular nature of secreted progranulin and provide evidence that progranul...

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Autori principali: Nguyen, Andrew D., Nguyen, Thi A., Cenik, Basar, Yu, Gang, Herz, Joachim, Walther, Tobias C., Davidson, W. Sean, Farese, Robert V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605681/
https://ncbi.nlm.nih.gov/pubmed/23364791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441949
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