Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation

TAR DNA binding protein 43 kDa (TDP-43) is a ribonuclear protein regulating many aspects of RNA metabolism. Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD) are fatal neurodegenerative diseases with the presence of TDP-43 aggregates in neuronal cells. Chaperone Mediat...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Ormeño, Fernando, Hormazabal, Juan, Moreno, José, Riquelme, Felipe, Rios, Javiera, Criollo, Alfredo, Albornoz, Amelina, Alfaro, Iván E., Budini, Mauricio
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7040037/
https://ncbi.nlm.nih.gov/pubmed/32132902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2020.00019
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