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Chaperone Mediated Autophagy in the Crosstalk of Neurodegenerative Diseases and Metabolic Disorders

Chaperone Mediated Autophagy (CMA) is a lysosomal-dependent protein degradation pathway. At least 30% of cytosolic proteins can be degraded by this process. The two major protein players of CMA are LAMP-2A and HSC70. While LAMP-2A works as a receptor for protein substrates at the lysosomal membrane,...

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Bibliographische Detailangaben
Veröffentlicht in:Front Endocrinol (Lausanne)
Hauptverfasser: Alfaro, Iván E., Albornoz, Amelina, Molina, Alfredo, Moreno, José, Cordero, Karina, Criollo, Alfredo, Budini, Mauricio
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365421/
https://ncbi.nlm.nih.gov/pubmed/30766511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2018.00778
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