Acute Overexpression of Myc in Intestinal Epithelium Recapitulates Some but Not All the Changes Elicited by Wnt/β-Catenin Pathway Activation

gan Finch, Andrew J., Soucek, Laura, Junttila, Melissa R., Swigart, Lamorna Brown, Evan, Gerard I.
Cyhoeddwyd 2009

Castration-Resistant Lgr5(+) Cells Are Long-Lived Stem Cells Required for Prostatic Regeneration

gan Wang, Bu-er, Wang, Xi, Long, Jason E., Eastham-Anderson, Jeff, Firestein, Ron, Junttila, Melissa R.
Cyhoeddwyd yn Stem Cell Reports (2015)

Distinct thresholds govern Myc’s biological output in vivo

gan Daniel, J. Murphy, Junttila, Melissa R., Pouyet, Laurent, Karnezis, Anthony, Shchors, Ksenya, Bui, Duyen A., Brown-Swigart, Lamorna, Johnson, Leisa, Evan, Gerard. I.
Cyhoeddwyd 2008

Selective activation of p53-mediated tumour suppression in high-grade tumours

gan Junttila, Melissa R., Karnezis, Anthony, Garcia, Daniel, Madriles, Francesc, Kortlever, Roderik M., Rostker, Fanya, Brown-Swigart, Lamorna, Pham, David M., Seo, Youngho, Evan, Gerard I., Martins, Carla P.
Cyhoeddwyd 2010

Quantification of Tumor Burden in a Genetically Engineered Mouse Model of Lung Cancer by Micro-CT and Automated Analysis()

gan Barck, Kai H., Bou-Reslan, Hani, Rastogi, Ujjawal, Sakhuja, Timothy, Long, Jason E., Molina, Rafael, Lima, Anthony, Hamilton, Patricia, Junttila, Melissa R., Johnson, Leisa, Carano, Richard A.D.
Cyhoeddwyd yn Transl Oncol (2015)

PME-1 protects ERK pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

gan Puustinen, Pietri, Junttila, Melissa R., Vanhatupa, Sari, Sablina, Anna A., Hector, Melissa E., Teittinen, Kaisa, Raheem, Olayinka, Ketola, Kirsi, Lin, Shujun, Kast, Juergen, Haapasalo, Hannu, Hahn, William C., Westermarck, Jukka
Cyhoeddwyd 2009

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

gan Chung, Wei-Jen, Daemen, Anneleen, Cheng, Jason H., Long, Jason E., Cooper, Jonathan E., Wang, Bu-er, Tran, Christopher, Singh, Mallika, Gnad, Florian, Modrusan, Zora, Foreman, Oded, Junttila, Melissa R.
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2017)

Transcription factor Etv5 is essential for the maintenance of alveolar type II cells

gan Zhang, Zhen, Newton, Kim, Kummerfeld, Sarah K., Webster, Joshua, Kirkpatrick, Donald S., Phu, Lilian, Eastham-Anderson, Jeffrey, Liu, Jinfeng, Lee, Wyne P., Wu, Jiansheng, Li, Hong, Junttila, Melissa R., Dixit, Vishva M.
Cyhoeddwyd yn Proc Natl Acad Sci U S A (2017)

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

gan López-Arribillaga, Erika, Rodilla, Verónica, Colomer, Carlota, Vert, Anna, Shelton, Amy, Cheng, Jason H., Yan, Bing, Gonzalez-Perez, Abel, Junttila, Melissa R., Iglesias, Mar, Torres, Ferran, Albanell, Joan, Villanueva, Alberto, Bigas, Anna, Siebel, Christian W., Espinosa, LLuís
Cyhoeddwyd yn Nat Commun (2018)

A stromal niche defined by expression of the transcription factor Wilms tumor 1 mediates programming and homeostasis of cavity-resident macrophages

gan Buechler, Matthew B., Kim, Ki-Wook, Onufer, Emily J., Williams, Jesse W., Little, Christine C., Dominguez, Claudia X., Li, Qingling, Sandoval, Wendy, Cooper, Jonathan E., Harris, Charles A., Junttila, Melissa R., Randolph, Gwendalyn J., Turley, Shannon J.
Cyhoeddwyd yn Immunity (2019)

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

gan Phan, Vernon T., Wu, Xiumin, Cheng, Jason H., Sheng, Rebecca X., Chung, Alicia S., Zhuang, Guanglei, Tran, Christopher, Song, Qinghua, Kowanetz, Marcin, Sambrone, Amy, Tan, Martha, Meng, Y. Gloria, Jackson, Erica L., Peale, Franklin V., Junttila, Melissa R., Ferrara, Napoleone
Cyhoeddwyd 2013

Therapeutic resistance and susceptibility is shaped by cooperative multi-compartment tumor adaptation

gan Long, Jason E., Wongchenko, Matthew J., Nickles, Dorothee, Chung, Wei-Jen, Wang, Bu-er, Riegler, Johannes, Li, Ji, Li, Qingling, Sandoval, Wendy, Eastham-Anderson, Jeff, Modrusan, Zora, Junttila, Teemu, Carano, Richard A. D., Foreman, Oded, Yan, Yibing, Junttila, Melissa R.
Cyhoeddwyd yn Cell Death Differ (2019)

Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1

gan Laine, Anni, Sihto, Harri, Come, Christophe, Rosenfeldt, Mathias T., Zwolinska, Aleksandra, Niemelä, Minna, Khanna, Anchit, Chan, Edward K., Kähäri, Veli-Matti, Kellokumpu-Lehtinen, Pirkko-Liisa, Sansom, Owen J., Evan, Gerard I., Junttila, Melissa R., Ryan, Kevin M., Marine, Jean-Christophe, Joensuu, Heikki, Westermarck, Jukka
Cyhoeddwyd 2013

Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

gan Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Cyhoeddwyd yn PLoS One (2017)

Correction: Combined MEK and ERK inhibition overcomes therapy-mediated pathway reactivation in RAS mutant tumors

gan Merchant, Mark, Moffat, John, Schaefer, Gabriele, Chan, Jocelyn, Wang, Xi, Orr, Christine, Cheng, Jason, Hunsaker, Thomas, Shao, Lily, Wang, Stephanie J., Wagle, Marie-Claire, Lin, Eva, Haverty, Peter M., Shahidi-Latham, Sheerin, Ngu, Hai, Solon, Margaret, Eastham-Anderson, Jeffrey, Koeppen, Hartmut, Huang, Shih-Min A., Schwarz, Jacob, Belvin, Marcia, Kirouac, Daniel, Junttila, Melissa R.
Cyhoeddwyd yn PLoS One (2018)

Target arm affinities determine preclinical efficacy and safety of anti-HER2/CD3 bispecific antibody

gan Staflin, Karin, Zuch de Zafra, Christina L., Schutt, Leah K., Clark, Vanessa, Zhong, Fiona, Hristopoulos, Maria, Clark, Robyn, Li, Ji, Mathieu, Mary, Chen, Xiaocheng, Johnston, Jennifer, Low, Justin, Ybarra, Ryan, Slaga, Dionysos, Yang, Jihong, Ovacik, Meric, Dybdal, Noël O., Totpal, Klara, Junttila, Melissa R., Ellerman, Diego, Lee, Genee, Dennis, Mark S., Prell, Rodney, Junttila, Teemu T.
Cyhoeddwyd yn JCI Insight (2020)

Randomized Phase Ib/II Study of Gemcitabine Plus Placebo or Vismodegib, a Hedgehog Pathway Inhibitor, in Patients With Metastatic Pancreatic Cancer

gan Catenacci, Daniel V.T., Junttila, Melissa R., Karrison, Theodore, Bahary, Nathan, Horiba, Margit N., Nattam, Sreenivasa R., Marsh, Robert, Wallace, James, Kozloff, Mark, Rajdev, Lakshmi, Cohen, Deirdre, Wade, James, Sleckman, Bethany, Lenz, Heinz-Josef, Stiff, Patrick, Kumar, Pankaj, Xu, Peng, Henderson, Les, Takebe, Naoko, Salgia, Ravi, Wang, Xi, Stadler, Walter M., de Sauvage, Frederic J., Kindler, Hedy L.
Cyhoeddwyd yn J Clin Oncol (2015)

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

gan Patel, Snahel, Webster, Joshua D., Varfolomeev, Eugene, Kwon, Youngsu C., Cheng, Jason H., Zhang, Juan, Dugger, Debra L., Wickliffe, Kate E., Maltzman, Allie, Sujatha-Bhaskar, Swathi, Bir Kohli, Pawan, Ramaswamy, Sreema, Deshmukh, Gauri, Liederer, Bianca M., Fong, Rina, Hamilton, Greg, Lupardus, Patrick, Caplazi, Patrick, Lee, Wyne P., van Lookeren Campagne, Menno, Johnson, Adam, McKenzie, Brent S., Junttila, Melissa R., Newton, Kim, Vucic, Domagoj
Cyhoeddwyd yn Cell Death Differ (2019)