Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

Granulocyte-colony stimulating factor (G-CSF) promotes mobilization of CD11b(+)Gr1(+) myeloid cells and has been implicated in resistance to anti-VEGF therapy in mouse models. High G-CSF production has been associated with a poor prognosis in cancer patients. Here we show that activation of the RAS/...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Phan, Vernon T., Wu, Xiumin, Cheng, Jason H., Sheng, Rebecca X., Chung, Alicia S., Zhuang, Guanglei, Tran, Christopher, Song, Qinghua, Kowanetz, Marcin, Sambrone, Amy, Tan, Martha, Meng, Y. Gloria, Jackson, Erica L., Peale, Franklin V., Junttila, Melissa R., Ferrara, Napoleone
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625253/
https://ncbi.nlm.nih.gov/pubmed/23530240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1303302110
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados