VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

We generated VEGF-null fibrosarcomas from VEGF-loxP mouse embryonic fibroblasts to investigate the mechanisms of tumor escape after VEGF inactivation. These cells were found to be tumorigenic and angiogenic in vivo in spite of the absence of tumor-derived VEGF. However, VEGF derived from host stroma...

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Gepubliceerd in:EMBO J
Hoofdauteurs: Dong, Jianying, Grunstein, Jeremy, Tejada, Max, Peale, Frank, Frantz, Gretchen, Liang, Wei-Ching, Bai, Wei, Yu, Lanlan, Kowalski, Joe, Liang, Xiaohuan, Fuh, Germaine, Gerber, Hans-Peter, Ferrara, Napoleone
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2004
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Online toegang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514949/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15229650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600289
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