VEGF-null cells require PDGFR α signaling-mediated stromal fibroblast recruitment for tumorigenesis

We generated VEGF-null fibrosarcomas from VEGF-loxP mouse embryonic fibroblasts to investigate the mechanisms of tumor escape after VEGF inactivation. These cells were found to be tumorigenic and angiogenic in vivo in spite of the absence of tumor-derived VEGF. However, VEGF derived from host stroma...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Dong, Jianying, Grunstein, Jeremy, Tejada, Max, Peale, Frank, Frantz, Gretchen, Liang, Wei-Ching, Bai, Wei, Yu, Lanlan, Kowalski, Joe, Liang, Xiaohuan, Fuh, Germaine, Gerber, Hans-Peter, Ferrara, Napoleone
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC514949/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15229650/
https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600289
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