Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and ma...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Chung, Wei-Jen, Daemen, Anneleen, Cheng, Jason H., Long, Jason E., Cooper, Jonathan E., Wang, Bu-er, Tran, Christopher, Singh, Mallika, Gnad, Florian, Modrusan, Zora, Foreman, Oded, Junttila, Melissa R.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5754767/
https://ncbi.nlm.nih.gov/pubmed/29203670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708391114
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