GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strategies. Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum homeostasis and PI3K/AKT signaling, is overexpres...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Proc Natl Acad Sci U S A
Prif Awduron: Shen, Jieli, Ha, Dat P., Zhu, Genyuan, Rangel, Daisy F., Kobielak, Agnieszka, Gill, Parkash S., Groshen, Susan, Dubeau, Louis, Lee, Amy S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2017
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441757/
https://ncbi.nlm.nih.gov/pubmed/28461470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616060114
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg