GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice

Pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease in critical need of new therapeutic strategies. Here, we report that the stress-inducible 78-kDa glucose-regulated protein (GRP78/HSPA5), a key regulator of endoplasmic reticulum homeostasis and PI3K/AKT signaling, is overexpres...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Shen, Jieli, Ha, Dat P., Zhu, Genyuan, Rangel, Daisy F., Kobielak, Agnieszka, Gill, Parkash S., Groshen, Susan, Dubeau, Louis, Lee, Amy S.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
PNAS Plus
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5441757/
https://ncbi.nlm.nih.gov/pubmed/28461470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1616060114
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