Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic target to combat cancer development, progression and drug resistance. The biological consequences of prolonged reduction in expression of this essential chaperone which so far has been studied primaril...

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Publicat a:Sci Rep
Autors principals: Lee, Amy S., Brandhorst, Sebastian, Rangel, Daisy F., Navarrete, Gerardo, Cohen, Pinchas, Longo, Valter D., Chen, Jeannie, Groshen, Susan, Morgan, Todd E., Dubeau, Louis
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286507/
https://ncbi.nlm.nih.gov/pubmed/28145503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40919
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