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Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic target to combat cancer development, progression and drug resistance. The biological consequences of prolonged reduction in expression of this essential chaperone which so far has been studied primaril...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Lee, Amy S., Brandhorst, Sebastian, Rangel, Daisy F., Navarrete, Gerardo, Cohen, Pinchas, Longo, Valter D., Chen, Jeannie, Groshen, Susan, Morgan, Todd E., Dubeau, Louis
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286507/
https://ncbi.nlm.nih.gov/pubmed/28145503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40919
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