Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

GRP78, a multifunctional protein with potent cytoprotective properties, is an emerging therapeutic target to combat cancer development, progression and drug resistance. The biological consequences of prolonged reduction in expression of this essential chaperone which so far has been studied primaril...

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Published in:Sci Rep
Main Authors: Lee, Amy S., Brandhorst, Sebastian, Rangel, Daisy F., Navarrete, Gerardo, Cohen, Pinchas, Longo, Valter D., Chen, Jeannie, Groshen, Susan, Morgan, Todd E., Dubeau, Louis
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286507/
https://ncbi.nlm.nih.gov/pubmed/28145503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40919
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