The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK–Receptor Interactions

door Ferrao, Ryan, Lupardus, Patrick J.
Gepubliceerd in Front Endocrinol (Lausanne) (2017)

Phosphorylation of Xenopus Rad1 and Hus1 Defines a Readout for ATR Activation That Is Independent of Claspin and the Rad9 Carboxy Terminus

door Lupardus, Patrick J., Cimprich, Karlene A.
Gepubliceerd in 2006

The structure of Interleukin-23 reveals the molecular basis of p40 subunit sharing with IL-12

door Lupardus, Patrick J., Garcia, K. Christopher
Gepubliceerd in 2008

Analyzing the ATR-mediated checkpoint using Xenopus egg extracts

door Lupardus, Patrick J., Van, Christopher, Cimprich, Karlene A.
Gepubliceerd in 2007

Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Rα2

door Lupardus, Patrick J., Birnbaum, Michael E., Garcia, K. Christopher
Gepubliceerd in 2010

Receptor-mediated dimerization of JAK2 FERM domains is required for JAK2 activation

door Ferrao, Ryan D, Wallweber, Heidi JA, Lupardus, Patrick J
Gepubliceerd in eLife (2018)

Kinase inhibition in autoimmunity and inflammation

door Zarrin, Ali A., Bao, Katherine, Lupardus, Patrick, Vucic, Domagoj
Gepubliceerd in Nat Rev Drug Discov (2020)

Small molecule-induced allosteric activation of the V. cholerae RTX cysteine protease domain

door Lupardus, Patrick J., Shen, Aimee, Bogyo, Matthew, Garcia, K. Christopher
Gepubliceerd in 2008

Structural organization of a full-length gp130/LIF-R cytokine receptor transmembrane complex

door Skiniotis, Georgios, Lupardus, Patrick, Martick, Monika, Walz, Thomas, Garcia, K. Christopher
Gepubliceerd in 2008

CPDadh: A new peptidase family homologous to the cysteine protease domain in bacterial MARTX toxins

door Pei, Jimin, Lupardus, Patrick J, Garcia, K Christopher, Grishin, Nick V
Gepubliceerd in 2009

Structural Biology of Shared Cytokine Receptors

door Wang, Xinquan, Lupardus, Patrick, LaPorte, Sherry L., Garcia, K. Christopher
Gepubliceerd in 2009

A requirement for replication in activation of the ATR-dependent DNA damage checkpoint

door Lupardus, Patrick J., Byun, Tony, Yee, Muh-ching, Hekmat-Nejad, Mohammad, Cimprich, Karlene A.
Gepubliceerd in 2002

Structural basis of IFNα receptor recognition by TYK2

door Wallweber, Heidi J.A., Tam, Christine, Franke, Yvonne, Starovasnik, Melissa A., Lupardus, Patrick J.
Gepubliceerd in 2014

Structure of the pseudokinase–kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

door Lupardus, Patrick J., Ultsch, Mark, Wallweber, Heidi, Bir Kohli, Pawan, Johnson, Adam R., Eigenbrot, Charles
Gepubliceerd in 2014

K(+) channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors

door Wilke, Russell A, Lupardus, Patrick J, Grandy, David K, Rubinstein, Marcelo, Low, Malcolm J, Jackson, Meyer B
Gepubliceerd in 1999

Structural snapshots of full-length Jak1, a transmembrane gp130/IL-6/IL-6Rα cytokine receptor complex, and the receptor-Jak1 holocomplex

door Lupardus, Patrick J., Skiniotis, Georgios, Rice, Amanda J., Thomas, Christoph, Fischer, Suzanne, Walz, Thomas, Garcia, K. Christopher
Gepubliceerd in 2011

The Structural Basis for Class II Cytokine Receptor Recognition by JAK1

door Ferrao, Ryan, Wallweber, Heidi J.A., Ho, Hoangdung, Tam, Christine, Franke, Yvonne, Quinn, John, Lupardus, Patrick J.
Gepubliceerd in Structure (2016)

Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid

door Fong, Rina, Kajihara, Kimberly, Chen, Matthew, Hotzel, Isidro, Mariathasan, Sanjeev, Hazenbos, Wouter L.W., Lupardus, Patrick J.
Gepubliceerd in MAbs (2018)

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

door Bomgarden, Ryan D, Lupardus, Patrick J, Soni, Deena V, Yee, Muh-Ching, Ford, James M, Cimprich, Karlene A
Gepubliceerd in 2006

Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase η on ATR checkpoint signaling

door Bomgarden, Ryan D, Lupardus, Patrick J, Soni, Deena V, Yee, Muh-Ching, Ford, James M, Cimprich, Karlene A
Gepubliceerd in 2006