Distinct thresholds govern Myc’s biological output in vivo

Deregulated Myc triggers a variety of intrinsic tumor suppressor programs that serve to restrain Myc’s oncogenic potential. Since Myc activity is also required for normal cell proliferation, activation of intrinsic tumor suppression must be triggered only when Myc signaling is oncogenic. However, ho...

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Detalhes bibliográficos
Main Authors: Daniel, J. Murphy, Junttila, Melissa R., Pouyet, Laurent, Karnezis, Anthony, Shchors, Ksenya, Bui, Duyen A., Brown-Swigart, Lamorna, Johnson, Leisa, Evan, Gerard. I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2723751/
https://ncbi.nlm.nih.gov/pubmed/19061836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2008.10.018
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